人类和黑猩猩大脑中微小RNA的多样性。

Diversity of microRNAs in human and chimpanzee brain.

作者信息

Berezikov Eugene, Thuemmler Fritz, van Laake Linda W, Kondova Ivanela, Bontrop Ronald, Cuppen Edwin, Plasterk Ronald H A

机构信息

Hubrecht Laboratory-KNAW, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.

出版信息

Nat Genet. 2006 Dec;38(12):1375-7. doi: 10.1038/ng1914. Epub 2006 Oct 29.

DOI:10.1038/ng1914

PMID:17072315

Abstract

We used massively parallel sequencing to compare the microRNA (miRNA) content of human and chimpanzee brains, and we identified 447 new miRNA genes. Many of the new miRNAs are not conserved beyond primates, indicating their recent origin, and some miRNAs seem species specific, whereas others are expanded in one species through duplication events. These data suggest that evolution of miRNAs is an ongoing process and that along with ancient, highly conserved miRNAs, there are a number of emerging miRNAs.

摘要

我们使用大规模平行测序技术比较了人类和黑猩猩大脑中的微小RNA（miRNA）含量，鉴定出447个新的miRNA基因。许多新的miRNA在灵长类动物之外并不保守，这表明它们是近期起源的，一些miRNA似乎具有物种特异性，而另一些则通过复制事件在一个物种中得到扩展。这些数据表明，miRNA的进化是一个持续的过程，并且除了古老的、高度保守的miRNA之外，还有许多新出现的miRNA。