Sack Stefan, Kahlert Philip, Khandanpour Sasan, Kordish Igor, Budeus Marco, Naber Christoph, Philipp Sebastian, Möhlenkamp Stefan, Erbel Raimund
Klinik für Kardiologie, Westdeutsches Herzzentrum Essen, Zentrum für Innere Medizin, Universitätsklinikum Essen, Hufelandstrasse 55, 45122 Essen.
Herz. 2006 Oct;31(7):688-93. doi: 10.1007/s00059-006-2909-4.
Calcified aortic stenosis is the predominant valve disease. Patients affected are most commonly elderly people, who often show associated comorbidities like reduced left ventricular function, impaired renal function, and pulmonary hypertension. The risk of open-heart surgery is elevated. Balloon aortic valvuloplasty enables a reduction of symptoms, an increase in physical performance, and, therefore, an improved quality of life. However, a reduction in mortality cannot be reached with this method. New techniques and improved equipment induced a "revival" of balloon aortic valvuloplasty, which has been introduced almost 20 years ago. In addition, brachytherapy after balloon valvuloplasty has recently been investigated and represents an interesting approach to reduce early restenosis. The technical improvement of balloon valvuloplasty is the percutaneous heart valve, which is under present clinical investigation. The antegrade/transseptal and retrograde approaches are used, as is the transapical access to the left ventricle. Even if long-term results are not yet available and the procedures still require technical improvement, especially minimization of catheter size, percutaneous valve replacement is a new chapter in the treatment of the calcified aortic stenosis.
钙化性主动脉瓣狭窄是主要的瓣膜疾病。受影响的患者大多为老年人,他们常伴有如左心室功能减退、肾功能受损和肺动脉高压等合并症。心脏直视手术的风险增加。球囊主动脉瓣成形术可减轻症状、提高身体机能,从而改善生活质量。然而,这种方法无法降低死亡率。新技术和改良设备促使球囊主动脉瓣成形术“复兴”,该技术于近20年前被引入。此外,球囊瓣膜成形术后的近距离放射疗法最近也在研究中,是减少早期再狭窄的一种有趣方法。球囊瓣膜成形术的技术改进是经皮心脏瓣膜,目前正处于临床研究阶段。采用顺行/经房间隔和逆行途径,以及经心尖进入左心室的方法。尽管长期结果尚未可知,且这些手术仍需技术改进,尤其是导管尺寸的最小化,但经皮瓣膜置换术是钙化性主动脉瓣狭窄治疗的新篇章。