Knoop Christiane, Estenne Marc
Department of Chest Medicine, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Semin Respir Crit Care Med. 2006 Oct;27(5):521-33. doi: 10.1055/s-2006-954609.
Over the last decade, improvements in surgical techniques, lung preservation, immunosuppression, and management of ischemia-reperfusion injury and infections have contributed to increase the 1 year patient survival after lung transplantation to 70 to 80%. However, the incidence of acute rejection remains higher than after other types of solid organ transplantation, and long-term survival is threatened by bronchiolitis obliterans, which is thought to be a form of chronic allograft rejection. This article reviews major aspects of clinical presentation, risk factors, diagnosis, and management of acute and chronic rejection after lung transplantation.
在过去十年中，手术技术、肺保存、免疫抑制以及缺血再灌注损伤和感染管理方面的改进，已使肺移植术后患者的1年生存率提高到70%至80%。然而，急性排斥反应的发生率仍高于其他类型的实体器官移植，闭塞性细支气管炎（被认为是一种慢性移植物排斥反应形式）则威胁着长期生存。本文综述了肺移植术后急性和慢性排斥反应的临床表现、危险因素、诊断及管理等主要方面。
