肺移植后的急性和慢性排斥反应。
Acute and chronic rejection after lung transplantation.
作者信息
Knoop Christiane, Estenne Marc
机构信息
Department of Chest Medicine, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
出版信息
Semin Respir Crit Care Med. 2006 Oct;27(5):521-33. doi: 10.1055/s-2006-954609.
Over the last decade, improvements in surgical techniques, lung preservation, immunosuppression, and management of ischemia-reperfusion injury and infections have contributed to increase the 1 year patient survival after lung transplantation to 70 to 80%. However, the incidence of acute rejection remains higher than after other types of solid organ transplantation, and long-term survival is threatened by bronchiolitis obliterans, which is thought to be a form of chronic allograft rejection. This article reviews major aspects of clinical presentation, risk factors, diagnosis, and management of acute and chronic rejection after lung transplantation.
在过去十年中，手术技术、肺保存、免疫抑制以及缺血再灌注损伤和感染管理方面的改进，已使肺移植术后患者的1年生存率提高到70%至80%。然而，急性排斥反应的发生率仍高于其他类型的实体器官移植，闭塞性细支气管炎（被认为是一种慢性移植物排斥反应形式）则威胁着长期生存。本文综述了肺移植术后急性和慢性排斥反应的临床表现、危险因素、诊断及管理等主要方面。
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