Aslett Martin, Wood Valerie
Wellcome Trust Sanger Institute, Cambridge CB10 1HH, UK.
Yeast. 2006 Oct 15;23(13):913-9. doi: 10.1002/yea.1420.
In this review, we present an overview of the Gene Ontology (GO) structure and describe how the GO is implemented for Sz. pombe and made available via Sz. pombe GeneDB (http://www.genedb.org/genedb/pombe/). We give a detailed progress report of Sz. pombe GO annotation, providing the current status of both manual and automatic annotations. Fission yeast has at least one GO annotation for 98.3% of its genes (excluding annotations to 'unknown' terms), greater than the current percentage coverage for any other organism. Approximately 65% (3225 gene products) have at least one annotation to each of the three ontologies (biological process, cellular component and molecular function). Approximately 30% (1443 gene products) have GO terms derived directly from small-scale experiments in fission yeast, supporting the validity of fission yeast as a model eukaryote and a reference organism.
在本综述中，我们概述了基因本体论（GO）结构，并描述了GO在粟酒裂殖酵母中的实现方式以及如何通过粟酒裂殖酵母基因数据库（http://www.genedb.org/genedb/pombe/）获取。我们给出了粟酒裂殖酵母GO注释的详细进展报告，提供了手动和自动注释的当前状态。裂殖酵母至少98.3%的基因有一个GO注释（不包括对“未知”术语的注释），这一比例高于目前任何其他生物的覆盖率。约65%（3225个基因产物）对三个本体（生物过程、细胞组分和分子功能）中的每一个都至少有一个注释。约30%（1443个基因产物）的GO术语直接来源于裂殖酵母中的小规模实验，这支持了裂殖酵母作为模式真核生物和参考生物的有效性。
