用抗应激药物Deltaran纠正低抵抗力动物的脑缺血。

Correction of cerebral ischemia in low-resistant animals with an antistress drug Deltaran.

作者信息

Gannushkina I V, Konorova I L, Koplik E V, Antelava A L

机构信息

Institute of Neurology, Russian Academy of Medical Sciences, Moscow.

出版信息

Bull Exp Biol Med. 2006 Mar;141(3):288-91. doi: 10.1007/s10517-006-0152-x.

DOI:10.1007/s10517-006-0152-x

PMID:17073141

Abstract

Deltaran decreased the amplitude of EEG slow waves and restored neuronal reactivity after carotid artery occlusion in Wistar rats sensitive to cerebral ischemia. Deltaran had no effect on local cerebral blood flow. This drug increased blood supply to a unit of neuronal activity in the brain of intact animals during the acute stage of cerebral ischemia, provided 100% survival rate of rats with cerebral ischemia, and prevented the development of neurological symptoms in survivors. Animal experiments proved the possibility of correcting cerebral ischemia with antistress drug Deltaran.

摘要

在对脑缺血敏感的Wistar大鼠中，Deltaran降低了脑电图慢波的振幅，并在颈动脉闭塞后恢复了神经元反应性。Deltaran对局部脑血流没有影响。在脑缺血急性期，这种药物增加了完整动物大脑中单位神经元活动的血液供应，使脑缺血大鼠的存活率达到100%，并预防了存活者神经症状的发展。动物实验证明了用抗应激药物Deltaran纠正脑缺血的可能性。