通过流动聚焦装置形成的脂质包被单分散微泡的长期稳定性。
Long-term stability by lipid coating monodisperse microbubbles formed by a flow-focusing device.
作者信息
Talu Esra, Lozano Monica M, Powell Robert L, Dayton Paul A, Longo Marjorie L
机构信息
Department of Chemical Engineering & Materials Science and Department of Biomedical Engineering, University of California, Davis, California 95616, USA.
出版信息
Langmuir. 2006 Nov 7;22(23):9487-90. doi: 10.1021/la062095+.
Abstract
In this letter, the long-term stabilization of monodisperse microbubbles produced by flow focusing is demonstrated using lipid encapsulation. Fluorescence microscopy, high-speed camera imaging, and particle size analysis were used to investigate the roles of lipid phase behavior, dissolution, Ostwald ripening, and coalescence in the stability of microbubbles formed by flow focusing. It was found that these behaviors were controlled through compositional changes with respect to lipid, emulsifier, and viscosity agents. Microbubbles coated with lipid and PEG emulsifier in a viscous solution were found to contain an extremely narrow size distribution (diameter(av) = 51 microm, standard deviation = 4 microm), which was maintained for up to several months.
摘要
在这封信中，展示了使用脂质封装实现流动聚焦产生的单分散微泡的长期稳定性。利用荧光显微镜、高速相机成像和粒度分析来研究脂质相行为、溶解、奥斯特瓦尔德熟化和聚结在流动聚焦形成的微泡稳定性中的作用。结果发现，这些行为可通过脂质、乳化剂和增稠剂的成分变化来控制。发现在粘性溶液中涂有脂质和聚乙二醇乳化剂的微泡具有极窄的尺寸分布（平均直径 = 51微米，标准偏差 = 4微米），这种分布可保持长达数月。
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