Ramji D P, Singh N N, Foka P, Irvine S A, Arnaoutakis K
Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK.
Biochem Soc Trans. 2006 Dec;34(Pt 6):1141-4. doi: 10.1042/BST0341141.
The regulation of macrophage cholesterol homoeostasis is of crucial importance in the pathogenesis of atherosclerosis, an underlying cause of heart attack and stroke. Several recent studies have revealed a critical role for the cytokine TGF-beta (transforming growth factor-beta), a key regulator of the immune and inflammatory responses, in atherogenesis. We discuss here the TGF-beta signalling pathway and its role in this disease along with the outcome of our recent studies on the action of the cytokine on the expression of key genes implicated in the uptake or efflux of cholesterol by macrophages and the molecular mechanisms underlying such regulation.
巨噬细胞胆固醇稳态的调节在动脉粥样硬化的发病机制中至关重要，动脉粥样硬化是心脏病发作和中风的潜在病因。最近的几项研究揭示了细胞因子TGF-β（转化生长因子-β）在动脉粥样硬化形成中起着关键作用，TGF-β是免疫和炎症反应的关键调节因子。我们在此讨论TGF-β信号通路及其在该疾病中的作用，以及我们最近关于该细胞因子对巨噬细胞胆固醇摄取或流出相关关键基因表达作用的研究结果，以及这种调节的分子机制。
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