Shany Eilon, Goldstein Esther, Khvatskin Sonia, Friger Michael D, Heiman Nurit, Goldstein Miri, Karplus Michael, Galil Aharon
Department of Neonatology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Pediatr Neurol. 2006 Nov;35(5):335-42. doi: 10.1016/j.pediatrneurol.2006.06.007.
The aim of this study was to correlate amplitude-integrated electroencephalography soon after birth with neurodevelopmental outcome in children who suffered from hypoxic-ischemic encephalopathy. Near term infants with hypoxic-ischemic encephalopathy and amplitude-integrated electroencephalography recording before 6 hours of age were included. Neurologic and cognitive outcome were assessed at 30 months of age and over. Outcome was correlated with either the pattern or voltage of the tracing. Thirty-nine infants were included. Eight died in the immediate neonatal period. At the age of 3 and 6 hours, sensitivity of low voltage to poor outcome was 33% and 42% respectively and of burst suppression pattern to poor outcome was 83% and 75% respectively. Association of voltage to outcome was significant only at 6 hours of age (P = 0.025). Association of pattern to outcome was significant both at 3 and 6 hours of age (P = 0.003, 0.008). These data on amplitude-integrated electroencephalography predictive value early in life were similar to previous studies. Burst suppression pattern, as early as 3 hours of age, is associated with poor outcome. At the age of 6 hours, both low voltage and burst suppression are associated with poor outcome. Pattern seems more sensitive than voltage.
本研究旨在探讨出生后不久的振幅整合脑电图与缺氧缺血性脑病患儿神经发育结局之间的相关性。纳入近足月缺氧缺血性脑病患儿且在出生6小时内进行了振幅整合脑电图记录。在30个月及以上时评估神经和认知结局。结局与脑电图的图形或电压相关。共纳入39例婴儿。8例在新生儿早期死亡。在3小时和6小时时，低电压对不良结局的敏感度分别为33%和42%，爆发抑制图形对不良结局的敏感度分别为83%和75%。电压与结局的相关性仅在6小时时具有统计学意义（P = 0.025）。图形与结局的相关性在3小时和6小时时均具有统计学意义（P = 0.003，0.008）。这些关于生命早期振幅整合脑电图预测价值的数据与先前的研究相似。爆发抑制图形早在3小时时就与不良结局相关。在6小时时，低电压和爆发抑制均与不良结局相关。图形似乎比电压更敏感。
