从典型抗精神病药物换用奥氮平后慢性精神分裂症患者丘脑体积减小
Reduced thalamic volume in patients with chronic schizophrenia after switching from typical antipsychotic medications to olanzapine.
作者信息
Khorram Babak, Lang Donna J, Kopala Lili C, Vandorpe Robert A, Rui Qing, Goghari Vina M, Smith Geoffrey N, Honer William G
机构信息
Centre for Complex Disorders, VGH Research Pavilion, Rm. 203-828 West 10th Ave., Vancouver, BC, Canada V5Z 1L8.
出版信息
Am J Psychiatry. 2006 Nov;163(11):2005-7. doi: 10.1176/ajp.2006.163.11.2005.
OBJECTIVE
The authors performed a longitudinal study of the effects on thalamic volume of switching from typical to atypical antipsychotic medications.
METHOD
Magnetic resonance imaging scans were acquired from 10 subjects with chronic schizophrenia taking typical antipsychotics and 20 healthy volunteers. Subjects with schizophrenia were switched to olanzapine; both groups were rescanned.
RESULTS
At baseline, thalamic volumes in subjects with chronic schizophrenia were 5.8% greater than those of healthy volunteers. At follow-up, there was no significant difference between groups. Additional analysis revealed a significant positive correlation between baseline thalamic volume and dosage of typical antipsychotic medication. Higher dosages at baseline were correlated with larger reductions in volume after the switch to olanzapine.
CONCLUSIONS
Antipsychotic medication effects may be a factor in the wide range of thalamic volume differences reported between subjects with schizophrenia and healthy volunteers.
目的
作者进行了一项纵向研究，以探讨从典型抗精神病药物转换为非典型抗精神病药物对丘脑体积的影响。
方法
对10名服用典型抗精神病药物的慢性精神分裂症患者和20名健康志愿者进行磁共振成像扫描。精神分裂症患者换用奥氮平；两组均再次扫描。
结果
基线时，慢性精神分裂症患者的丘脑体积比健康志愿者大5.8%。随访时，两组之间无显著差异。进一步分析显示，基线丘脑体积与典型抗精神病药物剂量之间存在显著正相关。基线时剂量越高，换用奥氮平后体积减少越大。
结论
抗精神病药物的作用可能是精神分裂症患者与健康志愿者之间报道的丘脑体积差异范围广泛的一个因素。
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