Wang Jun, Ho Lap, Zhao Zhong, Seror Ilana, Humala Nelson, Dickstein Dara L, Thiyagarajan Meenakshisundaram, Percival Susan S, Talcott Stephen T, Pasinetti Giulio Maria
Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Pl., New York, NY 10029, USA.
FASEB J. 2006 Nov;20(13):2313-20. doi: 10.1096/fj.06-6281com.
Recent studies suggest that moderate red wine consumption reduces the incidence of Alzheimer's disease (AD) clinical dementia. Using Tg2576 mice, which model AD-type amyloid beta-protein (Abeta) neuropathology, we tested whether moderate consumption of the red wine Cabernet Sauvignon modulates AD-type neuropathology and cognitive deterioration. The wine used in the study was generated using Cabernet Sauvignon grapes from Fresno, California, and was delivered to Tg2576 in a final concentration of approximately 6% ethanol. We found that Cabernet Sauvignon significantly attenuated AD-type deterioration of spatial memory function and Abeta neuropathology in Tg2576 mice relative to control Tg2576 mice that were treated with either a comparable amount of ethanol or water alone. Chemical analysis showed the Cabernet Sauvignon used in this study contains a very low content of resveratrol (0.2 mg/L), 10-fold lower than the minimal effective concentration shown to promote Abeta clearance in vitro. Our studies suggest Cabernet Sauvignon exerts a beneficial effect by promoting nonamyloidogenic processing of amyloid precursor protein, which ultimately prevents the generation of Abeta peptides. This study supports epidemiological evidence indicating that moderate wine consumption, within the range recommended by the FDA dietary guidelines of one drink per day for women and two for men, may help reduce the relative risk for AD clinical dementia.
最近的研究表明，适量饮用红酒可降低阿尔茨海默病（AD）临床痴呆的发病率。我们使用Tg2576小鼠（该小鼠可模拟AD型淀粉样β蛋白（Aβ）神经病理学），测试了适量饮用赤霞珠红酒是否能调节AD型神经病理学和认知衰退。该研究中使用的红酒由加利福尼亚州弗雷斯诺的赤霞珠葡萄酿造而成，并以最终浓度约为6%乙醇的形式给予Tg2576小鼠。我们发现，与单独用等量乙醇或水处理的对照Tg2576小鼠相比，赤霞珠显著减轻了Tg2576小鼠的AD型空间记忆功能衰退和Aβ神经病理学。化学分析表明，本研究中使用的赤霞珠白藜芦醇含量极低（0.2毫克/升），比体外促进Aβ清除的最低有效浓度低10倍。我们的研究表明，赤霞珠通过促进淀粉样前体蛋白的非淀粉样生成加工发挥有益作用，最终防止Aβ肽的产生。这项研究支持了流行病学证据，表明在FDA饮食指南建议的范围内适量饮酒（女性每天一杯，男性每天两杯）可能有助于降低AD临床痴呆的相对风险。
