克兰费尔特综合征（核型47，XXY）与精神分裂症谱系病理学。

Klinefelter's syndrome (karyotype 47,XXY) and schizophrenia-spectrum pathology.

作者信息

van Rijn Sophie, Aleman André, Swaab Hanna, Kahn René

机构信息

Experimental Experimental Psychology, Helmholtz Instituut, Universiteit Utrecht, PO Box 80125, 3508 TC Utrecht, The Netherlands.

出版信息

Br J Psychiatry. 2006 Nov;189:459-60. doi: 10.1192/bjp.bp.105.008961.

DOI:10.1192/bjp.bp.105.008961

PMID:17077438

Abstract

Klinefelter's syndrome, characterised by a 47,XXY chromosomal pattern, has largely been associated with physical abnormalities. Here, we report high levels of schizophrenia-spectrum pathology in 32 men with this syndrome in comparison with 26 healthy controls. This may have implications for treatment of have implications for treatment of Klinefelter's syndrome and suggests that the X chromosome may be involved in the aetiology of schizophrenia.

摘要

克兰费尔特综合征以47,XXY染色体模式为特征，很大程度上与身体异常有关。在此，我们报告了32名患有该综合征的男性与26名健康对照相比，精神分裂症谱系病理学水平较高。这可能对克兰费尔特综合征的治疗有影响，并表明X染色体可能参与精神分裂症的病因学。