Jackson Lisa A, Neuzil Kathleen M, Baggs James, Davis Robert L, Black Steve, Yamasaki Kristi M, Belongia Ed, Zangwill Kenneth M, Mullooly John, Nordin James, Marcy S Michael, DeStefano Frank
Group Health Center for Health Studies, Seattle, Washington, USA.
Pediatrics. 2006 Nov;118(5):2032-7. doi: 10.1542/peds.2006-1422.
Children <9 years of age do not respond optimally to a first dose of trivalent inactivated influenza vaccine, and so 2 doses of trivalent inactivated influenza vaccine are recommended for children <9 years of age who are being vaccinated for the first time. We conducted a population-based retrospective cohort study to evaluate compliance with the 2-dose trivalent inactivated influenza vaccine recommendations.
We evaluated 125,928 children 6 months through 8 years of age who were enrolled in health maintenance organizations in the United States participating in the Vaccine Safety Datalink project and who received their first dose of trivalent inactivated influenza vaccine in the 2001-2002, 2002-2003, or 2003-2004 influenza seasons.
Compliance with the 2 dose recommendations varied by age group and influenza season. Among children 6 to 23 months of age, the proportion of first-vaccinated children who received a second vaccination was 44% in 2001-2002, 54% in 2002-2003, and 29% in 2003-2004. Among children 2 to 8 years of age, the corresponding proportions were 15%, 24%, and 12%, respectively. In all seasons, compliance with the second vaccination was highest in children first vaccinated by mid-November.
The majority of children who received their first dose of trivalent inactivated influenza vaccine did not complete the 2-dose series. The recently expanded recommendation for universal vaccination of children 6 to 59 months of age and their household contacts will substantially increase the number of children targeted for a first influenza vaccination. Noncompliance with the 2-dose trivalent inactivated influenza vaccine series may be associated with suboptimal protection against infection, which may impact the magnitude of the direct and indirect benefits achieved by the vaccination program.
9岁以下儿童对第一剂三价灭活流感疫苗的反应并非最佳，因此建议首次接种疫苗的9岁以下儿童接种2剂三价灭活流感疫苗。我们开展了一项基于人群的回顾性队列研究，以评估对2剂三价灭活流感疫苗接种建议的依从性。
我们评估了125928名6个月至8岁的儿童，这些儿童加入了参与疫苗安全数据链项目的美国健康维护组织，并在2001 - 2002年、2002 - 2003年或2003 - 2004年流感季节接种了第一剂三价灭活流感疫苗。
对2剂接种建议的依从性因年龄组和流感季节而异。在6至23个月大的儿童中，首次接种疫苗后接受第二次接种的儿童比例在2001 - 2002年为44%，2002 - 2003年为54%，2003 - 2004年为29%。在2至8岁的儿童中，相应比例分别为15%、24%和12%。在所有季节中，11月中旬之前首次接种疫苗的儿童对第二次接种的依从性最高。
大多数接种了第一剂三价灭活流感疫苗的儿童未完成2剂接种程序。最近扩大的针对6至59个月大儿童及其家庭接触者普遍接种疫苗的建议将大幅增加首次接种流感疫苗的儿童数量。不遵守2剂三价灭活流感疫苗接种程序可能与对感染的保护不足有关，这可能会影响疫苗接种计划所实现的直接和间接效益的程度。
