Lefrak Linda, Burch Kelly, Caravantes Rheta, Knoerlein Kim, DeNolf Nancy, Duncan Jill, Hampton Frances, Johnston Celeste, Lockey Debbie, Martin-Walters Cassandra, McLendon Debra, Porter Melinda, Richardson Cliff, Robinson Cathy, Toczylowski Krystyna
Children's Hospital and Research Center, 747 52nd St, Neonatology, Oakland, CA 94609, USA.
Pediatrics. 2006 Nov;118 Suppl 2:S197-202. doi: 10.1542/peds.2006-0913R.
The objectives of this study were to review the use of oral sucrose for procedural pain management in NICUs, develop potentially better practice guidelines that are based on the best current evidence, and provide ideas for the implementation of these potentially better practices.
A collaboration of 12 centers of the Vermont Oxford Network worked together to review the strength of the evidence, clinical indications, dosage, administration, and contraindications and identify potential adverse effects for the use of sucrose analgesia as the basis of potentially better practices for sucrose analgesia guidelines. Several units implemented the guidelines.
Through reviews and inputs from all centers of the evidence, consensus was reached and guidelines that included indication, dosage per painful procedure, age-related dosage over 24 hours, method of delivery, and contraindications were developed.
Guidelines now are available from a consensus group, and suggestions for implementation of guidelines, based on implementation of other pain management strategies, were developed.
本研究的目的是回顾新生儿重症监护病房(NICU)中口服蔗糖用于程序性疼痛管理的情况,制定基于当前最佳证据的可能更好的实践指南,并为实施这些可能更好的实践提供思路。
佛蒙特牛津网络的12个中心合作,共同回顾证据的强度、临床适应症、剂量、给药方式和禁忌症,并确定使用蔗糖镇痛的潜在不良反应,以此作为制定蔗糖镇痛指南可能更好实践的基础。几个单位实施了这些指南。
通过对所有中心证据的回顾和投入,达成了共识,并制定了指南,包括适应症、每次疼痛操作的剂量、24小时内与年龄相关的剂量、给药方法和禁忌症。
现在有一个共识小组制定的指南,并且基于其他疼痛管理策略的实施,提出了指南实施的建议。