Ikeda Satoshi, Akahoshi Shoujiro, Sakai Akinori, Nakamura Toshitaka
Ken-ai Kinen Hospital, Department of Orthopedic Surgery.
Clin Calcium. 2006 Nov;16(11):1805-11.
The functional mechanism of glucocorticoid (GC)-induced osteoporosis is not fully understood. We examined to the effects of GC on bone turnover, minerals, structure, and bone strength in growing minipigs. GC administration caused prolongation of the period of bone tissue turnover in both trabecular and cortical bone and imbalance in bone formation and resorption, consequently leading to osteoporosis in growing minipigs. Bone structure were deteriorated both trabeculare and cortex. Deterioration of cortical bone rather than trabecular bone could play a role as main factor of bone fragilities in GC-induced osteoporosis.
糖皮质激素（GC）诱发骨质疏松症的功能机制尚未完全明确。我们研究了GC对生长中的小型猪骨转换、矿物质、结构及骨强度的影响。给予GC导致小梁骨和皮质骨的骨组织转换期延长，以及骨形成与吸收失衡，进而致使生长中的小型猪出现骨质疏松症。小梁骨和皮质骨的结构均恶化。在GC诱发的骨质疏松症中，皮质骨而非小梁骨的恶化可能是导致骨脆性增加的主要因素。
