Gozalo Alfonso S, Schwiebert Rebecca S, Lawson Gregory W
Division of Laboratory Animal Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
J Am Assoc Lab Anim Sci. 2006 Nov;45(6):63-6.
A group of 12 domestic pigeons (Columba livia domestica) was treated for capillariasis by use of fenbendazole at 30 mg/kg orally once daily for 5 d. After treatment, 8 of the 12 pigeons exhibited signs of anorexia, lethargy, and dehydration; these birds died within 2 d after the onset of clinical signs. A total of 6 birds were necropsied, and all had unremarkable gross findings. Microscopic examination of tissues revealed acute hemorrhagic enteritis, diffuse lymphoplasmacytic enteritis, small intestinal crypt necrosis, periportal lymphoplasmacytic hepatitis, bile duct hyperplasia, and renal tubular necrosis. Erythrocytes in blood samples collected from surviving birds demonstrated polychromasia compatible with a regenerative anemia. The clinical and histopathologic findings in these pigeons were consistent with recent reports of fenbendazole toxicity in domestic pigeons and other columbiform birds.
一组12只家鸽（Columba livia domestica）接受芬苯达唑治疗毛细线虫病，剂量为30毫克/千克，口服，每日一次，持续5天。治疗后，12只鸽子中有8只出现厌食、嗜睡和脱水症状；这些鸟在临床症状出现后2天内死亡。总共对6只鸟进行了尸检，所有鸟的大体检查结果均无异常。组织显微镜检查显示急性出血性肠炎、弥漫性淋巴细胞浆细胞性肠炎、小肠隐窝坏死、门周淋巴细胞浆细胞性肝炎、胆管增生和肾小管坏死。从存活鸟类采集的血液样本中的红细胞显示多染性，与再生性贫血相符。这些鸽子的临床和组织病理学发现与最近关于家鸽和其他鸽形目鸟类芬苯达唑毒性的报道一致。
