Strzalka Joseph, Xu Ting, Tronin Andrey, Wu Sophia P, Miloradovic Ivan, Kuzmenko Ivan, Gog Thomas, Therien Michael J, Blasie J Kent
Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, USA.
Nano Lett. 2006 Nov;6(11):2395-405. doi: 10.1021/nl062092h.
Extended conjugated chromophores containing (porphinato)zinc components that exhibit large optical polarizabilities and hyperpolarizabiliites are incorporated into amphiphilic 4-helix bundle peptides via specific axial histidyl ligation of the metal. The bundle's designed amphiphilicity enables vectorial orientation of the chromophore/peptide complex in macroscopic monolayer ensembles. The 4-helix bundle structure is maintained upon incorporation of two different chromophores at stoichiometries of 1-2 per bundle. The axial ligation site appears to effectively control the position of the chromophore along the length of the bundle.
含有（卟啉）锌成分且具有大光学极化率和超极化率的扩展共轭发色团，通过金属的特定轴向组氨酸连接被整合到两亲性4-螺旋束肽中。该束肽设计的两亲性使得发色团/肽复合物在宏观单层聚集体中能够进行矢量取向。在每个束以1-2的化学计量比掺入两种不同发色团后，4-螺旋束结构得以维持。轴向连接位点似乎有效地控制了发色团沿束长度的位置。
