Paradoxical reaction to epinephrine induced by beta-blockers in an anaphylactic shock induced by penicillin.

作者信息

Goddet Nathalie-Sybille, Descatha Alexis, Liberge Oliver, Dolveck François, Boutet Jérémie, Baer Michel, Fletcher Dominique, Templier François

机构信息

SAMU 92-SMUR Garches bOccupational Health Department, Raymond Poincaré teaching hospital, AP-HP, Garches, France.

出版信息

Eur J Emerg Med. 2006 Dec;13(6):358-60. doi: 10.1097/01.mej.0000217993.09364.35.

DOI:10.1097/01.mej.0000217993.09364.35

PMID:17091059

Abstract

Increased risk of severe and resistant anaphylactic shock is a rare and not widely known adverse effect of beta-blocker treatment. It is illustrated in a case of refractory anaphylactic shock occurring in a 47-year-old woman who received beta-blockers. Actually, beta-blockers increase the release of anaphylactic mediators, decrease the cardiovascular compensatory changes to the anaphylactic shock and promote paradoxical reflex vagotonic effects when using epinephrine.

摘要