局部动脉粥样硬化与前列腺癌之间的关联。
The association between local atherosclerosis and prostate cancer.
作者信息
Hager Martina, Mikuz Gregor, Bartsch Georg, Kolbitsch Christian, Moser Patrizia L
机构信息
Department of Pathology, Paracelsus Medical University Salzburg, Austria.
出版信息
BJU Int. 2007 Jan;99(1):46-8. doi: 10.1111/j.1464-410X.2006.06549.x.
OBJECTIVE
To morphometrically compare local atherosclerotic changes in cancerous prostate with those in noncancerous prostate specimens, as epidemiological studies report a positive association between the prevalence of general atherosclerosis and prostate cancer.
MATERIALS AND METHODS
The intima-to-media-ratio (IMR) of 538 prostate capsular tissue arteries was measured in 50 prostate cancer-positive and 29 prostate cancer-negative specimens (including 26 with benign prostatic hyperplasia and three with normal prostatic tissue).
RESULTS
An IMR of >1 was significantly associated with prostate cancer and a greater risk of prostate cancer (odds ratio 2.28). The IMR was >1 in cancer-positive specimens about twice as often as in cancer-negative tissue.
CONCLUSION
Local atherosclerosis (measured by the IMR) was more pronounced in prostate cancer-positive than in prostate cancer-negative specimens. The results support the view that men with local atherosclerotic lesions are at higher risk of prostate cancer.
目的
鉴于流行病学研究报告称全身动脉粥样硬化患病率与前列腺癌之间存在正相关，通过形态测量学比较癌性前列腺与非癌性前列腺标本中的局部动脉粥样硬化变化。
材料与方法
在50例前列腺癌阳性和29例前列腺癌阴性标本（包括26例良性前列腺增生和3例正常前列腺组织标本）中，测量了538条前列腺包膜组织动脉的内膜中层比（IMR）。
结果
IMR>1与前列腺癌及更高的前列腺癌风险显著相关（优势比2.28）。癌阳性标本中IMR>1的情况约为癌阴性组织中的两倍。
结论
癌阳性前列腺标本中的局部动脉粥样硬化（通过IMR测量）比癌阴性标本中更明显。结果支持这样的观点，即有局部动脉粥样硬化病变的男性患前列腺癌的风险更高。
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