[单纯疱疹病毒疫苗：前景]
[Herpes simplex virus vaccines: perspectives].
作者信息
Deback C, Huraux J-M
机构信息
Service de virologie du groupe hospitalier de la Pitié-Salpêtrière, 83, boulevard de l'Hôpital, 75651 Paris cedex 13, France.
出版信息
Rev Med Interne. 2007 Jan;28(1):16-21. doi: 10.1016/j.revmed.2006.09.022. Epub 2006 Oct 12.
PURPOSE
Despite effective antiviral therapy, infection with herpes simplex virus (HSV) is a critical public health issue, particularly genital herpes by its social and psychological burden and its contribution to the neonatal herpes and possibly to the HIV/AIDS pandemic.
CURRENT KNOWLEDGE
Many prophylactic and therapeutic vaccination approaches have been explored but no effective vaccine is presently available. In fact, as members of the Herpesviridae family, both HSV-1 and 2 types have genes involved in immune evasion.
FUTURE PROSPECTS
Further research is needed to define determinants of immunity in order to design more effective vaccines.
目的
尽管有有效的抗病毒治疗，但单纯疱疹病毒（HSV）感染仍是一个关键的公共卫生问题，尤其是生殖器疱疹，因其带来的社会和心理负担以及对新生儿疱疹的影响，还可能与艾滋病毒/艾滋病大流行有关。
当前认知
人们已经探索了许多预防性和治疗性疫苗接种方法，但目前尚无有效的疫苗。事实上，作为疱疹病毒科的成员，HSV - 1型和2型都有参与免疫逃避的基因。
未来展望
需要进一步研究来确定免疫决定因素，以便设计出更有效的疫苗。
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