Fernandez-Fresnedo G, de Francisco A, Ruiz J C, Cotorruelo J G, Alamillo C G, Valero R, Castañeda O, Zalduendo B, Izquierdo M J, Arias M
Nephrology Service, Universitary Hospital Marqués de Valdecilla, Santander, Spain.
Transplant Proc. 2006 Oct;38(8):2402-3. doi: 10.1016/j.transproceed.2006.08.051.
The National Kidney Foundation has developed guidelines for diagnosis and classification of chronic kidney disease (CKD) but it is not known whether they are applicable to renal transplant patients. This study analyzed the prevalence, the complications, and the influence of the CKD stage on the presence of complications in 506 stable transplant recipients. The mean age of the patients was 52.9 +/- 12 years, 34% were men, and the mean time after transplantation was 9.56 +/- 6.18 years. CKD was present in 90.3% with 9.9% were in CKD stages 4 or 5 with glomerular filtration rates lower than 30 mL/min per 1.73 m(2). The prevalence of anemia, phospho-calcium metabolism disorders, hypertriglyceridemia, and hypertension increased with the stage of CKD. We concluded that CKD and the complications of CKD were highly prevalent in renal transplant recipients. The classification of renal transplant patients by CKD stage may help clinicians to identify patients at increased risk and to target appropriate therapy to improve outcomes.
美国国家肾脏基金会已制定慢性肾脏病（CKD）的诊断和分类指南，但尚不清楚这些指南是否适用于肾移植患者。本研究分析了506例稳定的肾移植受者中CKD的患病率、并发症以及CKD分期对并发症发生情况的影响。患者的平均年龄为52.9±12岁，男性占34%，移植后的平均时间为9.56±6.18年。90.3%的患者存在CKD，其中9.9%处于CKD 4期或5期，肾小球滤过率低于30 mL/（min·1.73 m²）。贫血、磷钙代谢紊乱、高甘油三酯血症和高血压的患病率随CKD分期增加。我们得出结论，CKD及其并发症在肾移植受者中非常普遍。根据CKD分期对肾移植患者进行分类可能有助于临床医生识别风险增加的患者，并针对适当的治疗以改善预后。
