用于聚酮化合物全合成的现代羟醛缩合方法。
Modern aldol methods for the total synthesis of polyketides.
作者信息
Schetter Bernd, Mahrwald Rainer
机构信息
Chemisches Institut, Humboldt-Universität zu Berlin, Brook-Taylor-Strasse 2, 12489 Berlin, Germany.
出版信息
Angew Chem Int Ed Engl. 2006 Nov 20;45(45):7506-25. doi: 10.1002/anie.200602780.
The aldol reaction is one of the most important methods for the stereoselective construction of polyketide natural products, not only for nature but also for synthetic chemistry. The tremendous development in the field of aldol additions during the last 30 years has led to more and more total syntheses of complicated natural products. This Review illustrates by means of selected syntheses of natural products the new variants of the aldol addition. This includes aldol additions with various metal enolates, as well as metal-complex-catalyzed, organocatalytic, and biocatalytic methods.
羟醛反应是立体选择性构建聚酮天然产物最重要的方法之一，不仅对自然界而言，对合成化学来说也是如此。在过去30年里，羟醛加成领域的巨大发展使得越来越多复杂天然产物得以全合成。本综述通过对天然产物的选定合成实例阐述了羟醛加成的新变体。这包括与各种金属烯醇盐的羟醛加成，以及金属络合物催化、有机催化和生物催化方法。
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