一名唐氏综合征患者的黏液性水肿昏迷
Myxedema coma in a patient with Down's syndrome.
作者信息
Bansal Darpan, Nanda Ashish, Gupta Ekta, Croker Mary, Williams Misty L, Bacchus Amy, Simmons Debra, Erbland Marcia
出版信息
J Ark Med Soc. 2006 Nov;103(5):112-3.
INTRODUCTION
hyroid dysfunction is common in Down's syndrome, most common being hypothyroidism. Longstanding, untreated hypothyroidism can lead to myxedema coma.
METHODS
Here we report a patient with Down's syndrome who presented with myxedema coma.
DISCUSSION
The three essential elements for the diagnosis of myxedema coma include altered mental status, defective thermoregulation and a precipitating event or illness; all of these were present in our patient. Also, very high TSH, low T3 and T4, and the rapid response to the treatment with levothyroxine confirmed the diagnosis.
CONCLUSION
Patients with Down's syndrome should have regular screening for thyroid dysfunction.
引言
甲状腺功能障碍在唐氏综合征中很常见，最常见的是甲状腺功能减退。长期未经治疗的甲状腺功能减退可导致黏液性水肿昏迷。
方法
在此，我们报告一例患有黏液性水肿昏迷的唐氏综合征患者。
讨论
黏液性水肿昏迷诊断的三个基本要素包括精神状态改变、体温调节缺陷以及促发事件或疾病；所有这些在我们的患者中均存在。此外，非常高的促甲状腺激素、低三碘甲状腺原氨酸和甲状腺素，以及对左甲状腺素治疗的快速反应证实了诊断。
结论
唐氏综合征患者应定期筛查甲状腺功能障碍。
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