Fan Xiaoduo, Pristach Cynthia, Liu Emily Y, Freudenreich Oliver, Henderson David C, Goff Donald C
Schizophrenia Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Psychiatry Res. 2007 Jan 15;149(1-3):267-71. doi: 10.1016/j.psychres.2006.07.011. Epub 2006 Nov 16.
The present study examined the hypothesis that elevated serum levels of C-reactive protein (CRP) would be associated with more severe clinical symptoms in patients with schizophrenia. Twenty-six inpatients with schizophrenia or schizoaffective disorder were enrolled. Serum levels of CRP were measured, and each patient was assessed with the Positive and Negative Syndrome Scale (PANSS). Subjects with CRP levels above the normal range (CRP>0.50 mg/dl, elevated CRP group, N=5) scored significantly higher than those with CRP levels in the normal range (CRP<or=0.50 mg/dl, normal CRP group, N=21) on the PANSS total score, negative symptom subscale score and general psychopathology subscale score. There was no significant difference between the two groups on the PANSS positive symptom subscale score. An inflammatory process, as reflected by elevated serum levels of CRP, might be associated with more severe psychopathology in a subgroup of patients with schizophrenia.
精神分裂症患者血清C反应蛋白（CRP）水平升高与更严重的临床症状相关。招募了26名精神分裂症或分裂情感性障碍的住院患者。测量血清CRP水平，并使用阳性和阴性症状量表（PANSS）对每位患者进行评估。CRP水平高于正常范围的受试者（CRP>0.50mg/dl，CRP升高组，N=5）在PANSS总分、阴性症状分量表得分和一般精神病理学分量表得分上显著高于CRP水平在正常范围内的受试者（CRP≤0.50mg/dl，正常CRP组，N=21）。两组在PANSS阳性症状分量表得分上无显著差异。血清CRP水平升高所反映的炎症过程可能与一部分精神分裂症患者更严重的精神病理学相关。
