Civale John, Clarke Robert, Rivens Ian, ter Haar Gail
Joint Department of Physics, Institute of Cancer Research, Sutton, Surrey, UK.
Ultrasound Med Biol. 2006 Nov;32(11):1753-61. doi: 10.1016/j.ultrasmedbio.2006.06.005.
The use of focused ultrasound as a minimally invasive treatment for tumours is rapidly expanding. Target organs include the liver and kidneys. Both single element and phased array transducers may be used in the clinic. The presence of the rib cage presents a problem in high intensity focused ultrasound (HIFU) treatment planning, due to its high attenuation of the HIFU beam resulting in a loss of power at the focus as well as an increase in the risk of damage at the rib and to overlying tissues, including the skin. In this paper, a linearly segmented transducer, in which all active elements are driven in phase, has been investigated. The aim of the study was to investigate how a beam with a clinically useful profile could be achieved by removing the contribution of edge segments from one side of the transducer to the field. We have considered the case in which the HIFU beam approaches the rib cage during a treatment and investigated configurations of the transducer for which up to three segments on the edge are switched off. This problem has been studied initially using a linear acoustic field program to model the segmented transducer's acoustic beam profile. Experimental measurements of the transducer's acoustic field were performed using an automated beam plotting system. Temperature measurements were made on a rib surface for two transducer configurations using a fine wire thermocouple. A thermochromic liquid crystal material was used to assess qualitatively the heating pattern generated by the ultrasound beam. We show the rib sparing potential of the segmented transducer during HIFU treatment by demonstrating a reduction in the prefocal width of the ultrasound beam when edge segments are switched off. This has been predicted with the acoustic field model and demonstrated experimentally by acoustic field measurements and observations of the heating pattern generated by the ultrasound beam. A significant decrease in the temperature rise on a rib was observed in the case for which three edge segments were switched off compared with when all segments were active. We conclude that a segmented transducer extends the potential for treating liver tumours. In the case where the tumour lies behind, but close to the edge of, the ribs, energy loss at the focus and excessive heating in the rib and overlying tissue can be avoided by switching off edge segments.
聚焦超声作为一种肿瘤微创治疗手段,其应用正在迅速扩展。目标器官包括肝脏和肾脏。临床中可使用单元素换能器和相控阵换能器。由于肋骨对高强度聚焦超声(HIFU)束的高衰减,导致焦点处功率损失以及肋骨和包括皮肤在内的上层组织受损风险增加,肋骨的存在给HIFU治疗规划带来了问题。本文研究了一种所有有源元件同相驱动的线性分段换能器。该研究的目的是探究如何通过去除换能器一侧边缘段对声场的贡献来实现具有临床实用剖面的波束。我们考虑了HIFU束在治疗过程中接近肋骨的情况,并研究了可关闭边缘上多达三段的换能器配置。最初使用线性声场程序对分段换能器的声束剖面进行建模来研究这个问题。使用自动波束绘图系统对换能器的声场进行了实验测量。使用细丝热电偶对两种换能器配置下的肋骨表面进行了温度测量。使用热致变色液晶材料定性评估超声束产生的加热模式。通过展示关闭边缘段时超声束焦前宽度的减小,我们证明了分段换能器在HIFU治疗期间的肋骨保护潜力。这已通过声场模型预测,并通过声场测量和对超声束产生的加热模式的观察进行了实验验证。与所有段都激活时相比,在关闭三段边缘段的情况下,观察到肋骨上的温度上升显著降低。我们得出结论,分段换能器扩展了治疗肝肿瘤的潜力。在肿瘤位于肋骨后方但靠近肋骨边缘的情况下,通过关闭边缘段可以避免焦点处的能量损失以及肋骨和上层组织的过度加热。