肿瘤缺氧的正电子发射断层显像（PET）成像
PET imaging of tumour hypoxia.
作者信息
Padhani Anwar
机构信息
Paul Strickland Scanner Centre, Mount Vernon Hospital, Rickmansworth Road, Northwood, Middlesex, HA6 2RN, UK.
出版信息
Cancer Imaging. 2006 Oct 31;6(Spec No A):S117-21. doi: 10.1102/1470-7330.2006.9018.
Tumour hypoxia represents a significant challenge to the curability of human tumours leading to treatment resistance and enhanced tumour progression. Tumour hypoxia can be detected by non-invasive and invasive techniques but the inter-relationships between these remains largely undefined. [18F]Fluoromisonidazole-3-fluoro-1-(2'-nitro-1'-imidazolyl)-2-propanol ([18F]MISO) and Cu-diacetyl-bis(N4-methylthiosemicarbazone (Cu-ATSM)-positron emission tomography (PET), and blood oxygen level-dependent (BOLD)-magnetic resonance imaging (MRI) are the lead contenders for human application based on their non-invasive nature, ease of use and robustness, measurement of hypoxia status, validity, ability to demonstrate heterogeneity and general availability; PET techniques are the primary focus of this review.
肿瘤缺氧对人类肿瘤的可治愈性构成了重大挑战，导致治疗抵抗和肿瘤进展加速。肿瘤缺氧可通过非侵入性和侵入性技术检测，但这些技术之间的相互关系在很大程度上仍不明确。[18F]氟米索硝唑-3-氟-1-(2'-硝基-1'-咪唑基)-2-丙醇([18F]MISO)和铜-双乙酰双(N4-甲基硫代半卡巴腙)(Cu-ATSM)-正电子发射断层扫描(PET)以及血氧水平依赖(BOLD)-磁共振成像(MRI)，基于其非侵入性、易用性、稳健性、缺氧状态测量、有效性、显示异质性的能力和普遍可用性，是有望应用于人体的主要技术；PET技术是本综述的主要关注点。
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