大鼠中与抗伤害感受相关的导水管周围灰质中的精氨酸加压素来自下丘脑室旁核。
Arginine vasopressin in periaqueductal gray, which relates to antinociception, comes from hypothalamic paraventricular nucleus in the rat.
作者信息
Yang Jun, Yang Yu, Chen Jian-Min, Xu Hong-Tao, Liu Wen-Yan, Lin Bao-Cheng
机构信息
Institute for Pharmaceuticals and Medical Science, Guangdong Bangmin Pharmaceutical Co. Ltd., Jianghai Distract, Jiangmen, Guangdong 529000, China.
出版信息
Neurosci Lett. 2007 Jan 29;412(2):154-8. doi: 10.1016/j.neulet.2006.10.049. Epub 2006 Nov 22.
Hypothalamic paraventricular nucleus (PVN) is a major source of arginine vasopressin (AVP). Our previous work has proven that: (1) pain stimulation enhances PVN synthesis and secretion of AVP; (2) AVP in periaqueductal gray (PAG) plays a role in antinociception; (3) pain stimulation increases AVP concentration in PAG tissue. The present study was to investigate AVP source in PAG during pain modulation of the rat. The results showed that: (1) pain stimulation elevated AVP concentration in both PVN and PAG perfusion liquid, in which the peak of AVP concentration in PVN perfusion liquid occurred earlier than that in PAG perfusion liquid; (2) PVN cauterization weakened pain stimulation-induced PAG releasing AVP, in which the inhibitive effect of bilateral PVN cauterization showed stronger than that of unilateral PVN cauterization; (3) microinjection of l-glutamate sodium into PVN, which excited local neurons, increased AVP concentration in PAG perfusion liquid in a dose-dependent manner. The data suggest that AVP in PAG, which relates with pain modulation, comes from PVN.
下丘脑室旁核（PVN）是精氨酸加压素（AVP）的主要来源。我们之前的研究已经证明：（1）疼痛刺激可增强PVN中AVP的合成与分泌；（2）导水管周围灰质（PAG）中的AVP在抗伤害感受中发挥作用；（3）疼痛刺激可增加PAG组织中AVP的浓度。本研究旨在探究大鼠疼痛调制过程中PAG内AVP的来源。结果显示：（1）疼痛刺激使PVN和PAG灌流液中的AVP浓度升高，其中PVN灌流液中AVP浓度峰值出现的时间早于PAG灌流液；（2）PVN烧灼减弱了疼痛刺激诱导的PAG释放AVP，双侧PVN烧灼的抑制作用强于单侧PVN烧灼；（3）向PVN微量注射l-谷氨酸钠使局部神经元兴奋，PAG灌流液中AVP浓度呈剂量依赖性增加。这些数据表明，PAG中与疼痛调制相关的AVP来源于PVN。
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