Impairments in spatial memory retention of GFAP-apoE4 female mice.
作者信息
van Meer Peter, Acevedo Summer, Raber Jacob
机构信息
Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, United States.
出版信息
Behav Brain Res. 2007 Jan 25;176(2):372-5. doi: 10.1016/j.bbr.2006.10.024. Epub 2006 Nov 28.
Abstract
The human apolipoprotein E isoforms, apoE2, apoE3, and apoE4, have differential effects on brain function. Compared to apoE3, apoE4 increases the risk of age-related cognitive decline in humans and female mice expressing apoE in neurons. Here, we show impaired spatial memory retention in female mice expressing apoE4 in astrocytes compared to those expressing apoE3 in astrocytes or lacking apoE. Thus, apoE4 impairs cognition whether expressed in neurons or astrocytes.
摘要
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