Pinheiro Martina B, Bestetti Reinaldo B, Cordeiro José A
Int J Cardiol. 2007 Sep 14;121(1):93-4. doi: 10.1016/j.ijcard.2006.08.037. Epub 2006 Nov 28.
No previous study has examined the association of clinical variables and QTc interval dispersion in patients with Chagas-Hypertensive cardiomyopathy. Sixty-four patients with Chagas-Hypertensive cardiomyopathy were entered for the study. Seventy-one chronic Chagas' disease heart failure patients and 68 patients with Hypertensive cardiomyopathy heart failure were used in the comparison of QTc interval dispersion. The QTc interval dispersion was defined as the difference between maximum and minimum QTc. Median QTc interval dispersion was 75 (55) ms in patients with Chagas' cardiomyopathy, (56) 73 ms in patients with Hypertensive cardiomyopathy, and (87.3) 98 ms in patients with Chagas-Hypertensive cardiomyopathy (p>0.05). In patients with Chagas-Hypertensive cardiomyopathy, median QTc interval was (134) 100 ms in survivors and (87) 96 ms in nonsurvivors (p>0.05). Thus, QTc interval dispersion values in patients with Chagas-Hypertensive cardiomyopathy are not associated with mortality and similar to those found in patients with Chagas' cardiomyopathy and in patients with Hypertensive cardiomyopathy.
既往尚无研究探讨恰加斯-高血压性心肌病患者临床变量与QTc间期离散度之间的关联。本研究纳入了64例恰加斯-高血压性心肌病患者。在QTc间期离散度比较中,使用了71例慢性恰加斯病心力衰竭患者和68例高血压性心肌病心力衰竭患者。QTc间期离散度定义为最大QTc与最小QTc之间的差值。恰加斯心肌病患者的QTc间期离散度中位数为75(55)ms,高血压性心肌病患者为73(56)ms,恰加斯-高血压性心肌病患者为98(87.3)ms(p>0.05)。在恰加斯-高血压性心肌病患者中,存活者的QTc间期中位数为100(134)ms,非存活者为96(87)ms(p>0.05)。因此,恰加斯-高血压性心肌病患者的QTc间期离散度值与死亡率无关,且与恰加斯心肌病患者及高血压性心肌病患者的QTc间期离散度值相似。