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Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15951-6. doi: 10.1073/pnas.0604493103. Epub 2006 Oct 12.
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Human adaptive immune system Rag2-/-gamma(c)-/- mice.
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Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice.
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Development of a human adaptive immune system in cord blood cell-transplanted mice.
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HIV-1 actively replicates in naive CD4(+) T cells residing within human lymphoid tissues.
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