Huynh-Do U
Klinik und Poliklinik für Nephrologie und Hypertonie, Inselspital Bern.
Ther Umsch. 2006 Dec;63(12):783-7. doi: 10.1024/0040-5930.63.12.783.
Colchicine is a highly active alkaloid used in the treatment of acute inflammatory syndromes such as Mediterranean fever, M. Behçet or gouty arthritis. The two cases we present here illustrate exemplarily the pros and contras of colchicine therapy. In the first case, colchicine was successfully given for recurrent febrile attacks due to acute rheumatic fever. The second patient unfortunately had a fatal colchicine intoxication. The pharmacology of colchicine, the clinical features associated with overdose and the options for treatment are discussed. Colchicine should not be given in combination with macrolides, especially in patients with renal insufficiency.
秋水仙碱是一种活性很高的生物碱，用于治疗急性炎症综合征，如地中海热、白塞病或痛风性关节炎。我们在此呈现的两个病例示例性地说明了秋水仙碱治疗的利弊。在第一个病例中，秋水仙碱成功用于治疗急性风湿热引起的反复发热发作。不幸的是，第二个患者发生了致命的秋水仙碱中毒。本文讨论了秋水仙碱的药理学、过量用药相关的临床特征以及治疗选择。秋水仙碱不应与大环内酯类药物联合使用，尤其是肾功能不全的患者。
