Iarmonenko S P
Radiats Biol Radioecol. 2006 Sep-Oct;46(5):605-10.
Radiation-genetic effects are characterized by large quantitative difference. After the low dose radiation appearance of mutation is the largest in Drosophila, substantially lower in mice, especially if irradiation was protracted, and practically absent in humans. As the possible grounds of this difference the author consider the existence of non-specific repair mechanism, which has arouse during evolution for diminution of different detrimental impacts, including ionizing radiation. The efficacy of such mechanism of natural protection is determined by the efficacy of the repair mechanisms, which is elevated in compliance with specific life span, which is of necessity for its maintenance. The evolution has led to maximal development of this mechanism in human beings, and it is proved in particular in prevention of the hereditary effect of low-level radiation.
辐射遗传效应的特点是存在巨大的数量差异。低剂量辐射后,果蝇的突变出现率最高,小鼠的则低得多,尤其是在长期照射的情况下,而在人类中几乎不存在。作者认为这种差异的可能原因是存在非特异性修复机制,这种机制在进化过程中产生,用于减少包括电离辐射在内的各种有害影响。这种自然保护机制的功效取决于修复机制的功效,而修复机制的功效会随着特定寿命的延长而提高,这是维持该机制所必需的。进化导致这种机制在人类中得到最大程度的发展,这尤其体现在对低水平辐射遗传效应的预防上。