5-羟色氨酸与唐氏综合征患者的睡眠

5-Hydroxytryptophan and sleep in Down's syndrome.

作者信息

Petre-Quadens O, De Lee C

出版信息

J Neurol Sci. 1975 Nov;26(3):443-53. doi: 10.1016/0022-510x(75)90213-0.

Abstract

Polygraphic total night sleep electroencephalographic (EEG), electro-oculographic (EOG) and electromyographic (EMG) recordings have been made in 6 mongoloid infants who received oral 5-HTP for periods extending from 12 to 36 months. The doses were adapted to the infants' age and tolerance level. The oculomotor activity of paradoxical sleep (PS) was selectively analysed. The eye-movement (EM) density was significantly decreased in non-treated mongoloids as compared with that of normal age-related infants. Out of the 5-HTP-treated patients, however, the results in only 2 were within the limits for normal age-related infants. 5-HTP failed to induce any long-term differences in the EM frequencies. In fact, the drug had a short-term effect lasting up to 8 days. An increase in muscle tone and an improvement of motor behaviour were the only long-lasting results.

摘要

对6名接受口服5-羟色氨酸长达12至36个月的蒙古症婴儿进行了多导睡眠脑电图（EEG）、眼电图（EOG）和肌电图（EMG）全夜记录。剂量根据婴儿的年龄和耐受水平进行调整。对异相睡眠（PS）的动眼活动进行了选择性分析。与正常年龄相关的婴儿相比，未经治疗的蒙古症患者的眼动（EM）密度显著降低。然而，在接受5-羟色氨酸治疗的患者中，只有2人的结果在正常年龄相关婴儿的范围内。5-羟色氨酸未能在眼动频率上引起任何长期差异。事实上，该药物有长达8天的短期效应。肌张力增加和运动行为改善是唯一持久的结果。