一种基于非对映异位基团选择性分子内狄尔斯-阿尔德反应构建C9-取代反式氢化茚环的对映选择性去对称化方法。
An enantioselective desymmetrisation approach to C9-substituted trans-hydrindene rings based on a diastereotopic group-selective intramolecular Diels-Alder reaction.
作者信息
Azzi Nadia, Griffen Ed, Light Mark, Linclau Bruno
机构信息
University of Southampton, School of Chemistry, Highfield, Southampton, UKSO17 1BJ.
出版信息
Chem Commun (Camb). 2006 Dec 21(47):4909-11. doi: 10.1039/b607488j. Epub 2006 Oct 5.
DOI:10.1039/b607488j
PMID:17136243
Abstract
The synthesis of an achiral skipped bis(1,3-diene) substrate was achieved, which was shown to undergo an enantioselective, diastereotopic group-selective, intramolecular Diels-Alder reaction.
摘要
实现了一种非手性的间隔双（1,3-二烯）底物的合成，该底物被证明能发生对映选择性、非对映异位基团选择性的分子内狄尔斯-阿尔德反应。
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