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一名患肝脾性猫抓病儿童的异常结局。

An unusual outcome in a child with hepatosplenic cat-scratch disease.

作者信息

Vukelić Dalibor, Benić Branka, Bozinović Dragomir, Vuković Branka, Dakovic Rode Oktavija, Culig Zdravka, Vuković Jurica, Batinica Stipe, Visnjić Stjepan, Puljiz Ivan

机构信息

University Hospital for Infectious Diseases Dr. Fran Mihaljević, Zagreb, Croatia.

出版信息

Wien Klin Wochenschr. 2006 Oct;118(19-20):615-8. doi: 10.1007/s00508-006-0654-6.

Abstract

Typical cat-scratch disease (Bartonella henselae infection) in an immunocompetent child is usually associated with a history of scratch, bite or intimate contact with a cat. Most patients develop a non-tender papule in the scratch line after three to ten days. This may persist for only a few days or as long as two to three weeks. During the next two weeks or more, regional lymph nodes that drain the area gradually enlarge and then slowly resolve in more than 10% of patients. The nodes develop overlying erythema and may suppurate. Atypical forms of cat-scratch disease occur in a minority of cases and are characterized by ocular or neurological manifestations, hepatosplenic involvement, vertebral osteomyelitis, endocarditis etc. Immunocompromised individuals with B. henselae infection may develop bacillary angiomatosis, bacillary peliosis, and relapsing bacteremia. There have been several reports of hepatosplenic granulomas caused by B. henselae in immunocompetent children. We report a case of a 6-year-old boy with the hepatosplenic form of cat-scratch disease. Despite early diagnosis and long-term antimicrobial treatment, splenectomy could not be avoided.

摘要

免疫功能正常的儿童患典型猫抓病(汉赛巴尔通体感染)通常与有被猫抓伤、咬伤或密切接触史有关。大多数患者在三到十天后在抓伤部位出现一个无压痛的丘疹。此丘疹可能仅持续数天,也可能长达两到三周。在接下来的两周或更长时间里,引流该区域的局部淋巴结逐渐肿大,然后在超过10%的患者中缓慢消退。淋巴结出现红斑,可能会化脓。少数病例会出现非典型形式的猫抓病,其特征为眼部或神经表现、肝脾受累、脊椎骨髓炎、心内膜炎等。感染汉赛巴尔通体的免疫功能低下个体可能会发展为杆菌性血管瘤、杆菌性紫癜和复发性菌血症。有几篇关于免疫功能正常儿童中由汉赛巴尔通体引起肝脾肉芽肿的报道。我们报告一例6岁男孩患肝脾型猫抓病的病例。尽管早期诊断并进行了长期抗菌治疗,但仍无法避免脾切除术。

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