艾维玛，一种无毒的发酵小麦胚芽提取物，可诱导人HL-60早幼粒细胞白血病细胞凋亡并抑制核糖核苷酸还原酶。

Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells.

作者信息

Saiko Philipp, Ozsvar-Kozma Maria, Madlener Sibylle, Bernhaus Astrid, Lackner Andreas, Grusch Michael, Horvath Zsuzsanna, Krupitza Georg, Jaeger Walter, Ammer Kirsten, Fritzer-Szekeres Monika, Szekeres Thomas

机构信息

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, General Hospital of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

出版信息

Cancer Lett. 2007 Jun 8;250(2):323-8. doi: 10.1016/j.canlet.2006.10.018. Epub 2006 Nov 29.

DOI:10.1016/j.canlet.2006.10.018

PMID:17137710

Abstract

Avemar (MSC) is a nontoxic fermented wheat germ extract demonstrated to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in human HL-60 promyelocytic leukemia cells. After 24, 48, and 72 h of incubation, Avemar inhibited the growth of HL-60 cells with IC50 values of 400, 190, and 160 microg/ml, respectively. Incubation with MSC caused dose-dependent induction of apoptosis in up to 85% of tumor cells. In addition, Avemar attenuated the progression from G2-M to G0-G1 phase of the cell cycle and was also found to significantly reduce the in situ activity of ribonucleotide reductase, the key enzyme of de novo DNA synthesis. We conclude that Avemar exerts a number of beneficial effects which could support conventional chemotherapy of human malignancies.

摘要

艾维玛（MSC）是一种无毒的发酵小麦胚芽提取物，已证明能显著提高各种恶性肿瘤患者的生存率。我们研究了其对人HL-60早幼粒细胞白血病细胞的影响。孵育24、48和72小时后，艾维玛抑制HL-60细胞的生长，IC50值分别为400、190和160微克/毫升。与MSC孵育导致高达85%的肿瘤细胞发生剂量依赖性凋亡诱导。此外，艾维玛减弱了细胞周期从G2-M期到G0-G1期的进程，还发现其能显著降低核糖核苷酸还原酶（从头合成DNA的关键酶）的原位活性。我们得出结论，艾维玛发挥了多种有益作用，可支持人类恶性肿瘤的传统化疗。