Sand T
Department of Neurology, University Hospital of Trondheim, Regionsykehuset, Norway.
Electroencephalogr Clin Neurophysiol. 1991 Jul-Aug;80(4):292-7. doi: 10.1016/0168-5597(91)90112-b.
The correlations between clinical signs and BAEP latency, amplitude and dispersion variables were investigated in 98 multiple sclerosis patients. A new dispersion variable, the wave IV-V "shape ratio" (SR IV-V), correlated most strongly with brain-stem signs (i.e., nystagmus). Severely reduced wave IV-V amplitude was frequently found in patients with vertical nystagmus or internuclear ophthalmoplegia, and interpeak latency (IPL) III-V correlated most strongly with cerebellar dysfunction (i.e., ataxia). The results may reflect different localizing ability among the various BAEP variables. The association between ataxia and increased IPL III-V was significantly stronger for BAEP to C clicks than to R clicks. Patients with abnormal BAEPs to one polarity (C or R) but not to the other, had significantly more clinical dysfunction than patients with normal BAEPs to both C and R clicks. Hence, C vs. R discordance may be interpreted to indicate possible brain-stem dysfunction.
对98例多发性硬化症患者的临床体征与脑干听觉诱发电位（BAEP）潜伏期、波幅及离散度变量之间的相关性进行了研究。一个新的离散度变量，即波IV-V “形态比”（SR IV-V），与脑干体征（即眼球震颤）的相关性最强。在垂直性眼球震颤或核间性眼肌麻痹患者中，常发现波IV-V波幅严重降低，而峰间潜伏期（IPL）III-V与小脑功能障碍（即共济失调）的相关性最强。结果可能反映了不同BAEP变量之间不同的定位能力。对于BAEP对C短声的反应，共济失调与IPL III-V增加之间的关联明显强于对R短声的反应。BAEP对一种极性（C或R）异常而对另一种极性正常的患者，比BAEP对C和R短声均正常的患者有明显更多的临床功能障碍。因此，C与R的不一致可能被解释为提示可能存在脑干功能障碍。
