Thomsen Henrik S
Department of Diagnostic Radiology, Copenhagen University Hospital at Herlev, Herlev, Denmark.
Curr Opin Urol. 2007 Jan;17(1):70-6. doi: 10.1097/MOU.0b013e328011c96f.
The present review covers the European Society of Urogenital Radiology guidelines for safe use of contrast media of importance for referring urologists.
During the recent years contrast medium-induced nephropathy has become a hot topic. It is of importance to reduce its incidence. First of all, the patients at risk should be identified prior to the administration of a contrast medium, so that appropriate measures can be taken. Before intravenous administration of an iodinated agent but not before gadolinium-based and ultrasound agents, all patients should be questioned about the potential renal dysfunction at the time of referral, and only those who answer affirmative to at least one question should have their serum creatinine level determined. Before intraarterial injection, the serum creatinine should always be measured. In case of an abnormal level, another imaging procedure should be considered. If impossible, hydration should be instituted and administration of nephrotoxic drugs should be stopped. After administration, delayed reactions such as nephrogenic systemic fibrosis, thyreotoxicosis, skin rash, etc. may be seen. Interaction with isotope studies and biochemical analysis occurs too.
The awareness regarding the potential adverse reactions due to contrast media and the necessary precautions to be taken are of utmost importance both for radiologists and referring physicians. This is the only way to reduce their incidence.
本综述涵盖了欧洲泌尿生殖放射学会关于造影剂安全使用的指南,这对泌尿外科转诊医生很重要。
近年来,造影剂肾病已成为一个热门话题。降低其发病率很重要。首先,应在给予造影剂之前识别出有风险的患者,以便采取适当措施。在静脉注射碘剂之前,但不是在使用钆剂和超声造影剂之前,所有患者在转诊时都应被询问是否存在潜在的肾功能不全,只有那些对至少一个问题回答为肯定的患者才应测定其血清肌酐水平。在动脉内注射之前,应始终测量血清肌酐。如果水平异常,应考虑采用其他成像检查方法。如果无法做到,应进行水化治疗并停用肾毒性药物。给药后,可能会出现诸如肾源性系统性纤维化、甲状腺毒症、皮疹等延迟反应。与同位素研究和生化分析也会发生相互作用。
对于放射科医生和转诊医生而言,了解造影剂潜在的不良反应以及采取必要的预防措施至关重要。这是降低其发病率的唯一途径。