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普瑞巴林用于治疗疼痛性神经病变。

Pregabalin for the treatment of painful neuropathy.

作者信息

Sonnett Travis E, Setter Stephen M, Campbell R Keith

机构信息

Washington State University, College of Pharmacy, Family Home Care Corporation, 9922 E Montgomery Avenue, Suite 3, Spokane, WA 99206, USA.

出版信息

Expert Rev Neurother. 2006 Nov;6(11):1629-35. doi: 10.1586/14737175.6.11.1629.

Abstract

Pregabalin is an alpha(2)-delta ligand that binds to and modulates voltage-gated calcium channels, exerting its intended effect to reduce neuropathic pain. Pregabalin is the second of only two medications that are US FDA approved for the treatment of neuropathic pain associated with diabetic peripheral neuropathy; it is also the third medication for the treatment of postherpetic neuralgia. Currently, there are three pivotal clinical studies documenting the efficacy and safety of pregabalin for the treatment of painful diabetic neuropathy, and three clinical studies regarding the use of pregabalin for pain associated with postherpetic neuralgia. This article will review each of these studies, as well as provide a clinical review for the use of pregabalin in the treatment of neuropathic pain.

摘要

普瑞巴林是一种α₂-δ配体,可与电压门控钙通道结合并对其进行调节,从而发挥减轻神经性疼痛的预期效果。普瑞巴林是美国食品药品监督管理局(US FDA)批准用于治疗与糖尿病性周围神经病变相关的神经性疼痛的仅有的两种药物中的第二种;它也是用于治疗带状疱疹后神经痛的第三种药物。目前,有三项关键临床研究记录了普瑞巴林治疗疼痛性糖尿病神经病变的有效性和安全性,还有三项关于普瑞巴林用于治疗带状疱疹后神经痛相关疼痛的临床研究。本文将对这些研究逐一进行综述,并对普瑞巴林在治疗神经性疼痛中的应用进行临床综述。

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