Shoval Gal, Zalsman Gil, Apter Alan, Diller Robyne, Sher Leo, Weizman Abraham
Department of Child and Adolescent Psychiatry, Geha Mental Health Center, Petah Tiqva 49100, Israel.
Compr Psychiatry. 2007 Jan-Feb;48(1):1-7. doi: 10.1016/j.comppsych.2006.05.002. Epub 2006 Jun 30.
The comorbidity of schizophrenia/schizoaffective disorder and substance use is a major psychiatric concern that is associated with aggressive and suicidal behavior. This study investigated the clinical correlates and characterizes adolescent psychotic inpatients with and without comorbid substance use. We performed a retrospective study of 188 adolescent inpatients who were admitted between the years 1994 and 2004 to the inpatient unit of Geha Mental Health Center and who were diagnosed as suffering from either schizophrenia or schizoaffective disorder. The substance-using psychotic inpatients were found to have more relatives with substance-related disorders, fewer comorbid anxiety disorders, lower scores on the Brief Psychiatric Rating Scale and Hamilton Scale for Depression, higher scores on the Overt Aggression Scale, and they were more suicidal than the nonsubstance using inpatients. Adolescent inpatients with schizophrenia and schizoaffective who use substances possess differential clinical characteristics and particular correlates that justify adopting a specific approach to this high-risk clinical subgroup.
精神分裂症/分裂情感性障碍与物质使用的共病是一个主要的精神科问题，与攻击行为和自杀行为相关。本研究调查了有和没有共病物质使用的青少年精神病住院患者的临床相关因素并对其进行了特征描述。我们对188名青少年住院患者进行了一项回顾性研究，这些患者在1994年至2004年间入住Geha心理健康中心住院部，被诊断为患有精神分裂症或分裂情感性障碍。发现使用物质的精神病住院患者有更多患有物质相关障碍的亲属，共病焦虑症较少，简明精神病评定量表和汉密尔顿抑郁量表得分较低，明显攻击量表得分较高，并且他们比不使用物质的住院患者更易自杀。患有精神分裂症和分裂情感性障碍且使用物质的青少年住院患者具有不同的临床特征和特定的相关因素，这证明对这一高风险临床亚组应采取特定的方法。
