唑来膦酸对早期多发性骨髓瘤患者血清骨保护素的影响。
The effect of zoledronic acid on serum osteoprotegerin in early stage multiple myeloma.
作者信息
Martini Giuseppe, Gozzetti Alessandro, Gennari Luigi, Avanzati Annalisa, Nuti Ranuccio, Lauria Francesco
出版信息
Haematologica. 2006 Dec;91(12):1720-1.
PMID:17145616
Abstract
We evaluated the effect of zoledronic acid (ZA) on serum levels of osteoprotegerin (OPG) and the ligand for receptor activator of nuclear factor kappaB (RANKL) in patients with smoldering myeloma. In treated subjects we found an increase of OPG accounting for an effect of ZA on osteoblast and/or bone marrow stromal cells together with the direct effect on osteoclasts.
摘要
我们评估了唑来膦酸（ZA）对冒烟型骨髓瘤患者血清骨保护素（OPG）水平及核因子κB受体激活剂配体（RANKL）的影响。在接受治疗的受试者中，我们发现OPG增加，这说明ZA对成骨细胞和/或骨髓基质细胞有作用，同时对破骨细胞也有直接作用。
Zotero 插件