α粒子对人杂交细胞系的致瘤转化与乳腺X线摄影X射线的关系
Neoplastic transformation of a human hybrid cell line by alpha particles in relation to mammography X rays.
作者信息
Frankenberg-Schwager M, Spieren S, Pralle E, Frankenberg D
机构信息
University of Goettingen, Center of Radiology, Department of Nuclear Medicine, Von-Siebold-Strasse 3, D-37075 Goettingen, Germany.
出版信息
Radiat Prot Dosimetry. 2006;122(1-4):180-4. doi: 10.1093/rpd/ncl457. Epub 2006 Dec 4.
The hybrid cell line CGL1 is the only cell line which allows quantitation of neoplastic transformation in human cells. Hybrid cells were exposed to 3.4 MeV alpha particles or to mammography X rays (29 kV(p)) and both survival and neoplastic cell transformation were assayed. For comparison, previously published data obtained with 200 kV(p) X rays are also included. Alpha particles were significantly more efficient than 29 kV(p) X rays in cell killing. Surprisingly, the efficiency of mammography X rays for the induction of neoplastic cell transformation was close to that observed for alpha particles.
杂交细胞系CGL1是唯一能够对人类细胞中的肿瘤转化进行定量分析的细胞系。将杂交细胞暴露于3.4兆电子伏特的α粒子或乳腺X射线（29千伏峰值）下，然后对细胞存活率和肿瘤细胞转化情况进行检测。作为比较，还纳入了之前用200千伏峰值X射线获得的已发表数据。在细胞杀伤方面，α粒子比29千伏峰值X射线的效率显著更高。令人惊讶的是，乳腺X射线诱导肿瘤细胞转化的效率与α粒子所观察到的效率相近。
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