Löfberg Christian, Grigg Ronald, Keep Ann, Derrick Andrew, Sridharan Visuvanathar, Kilner Colin
Molecular Innovation, Diversity and Automated Synthesis Centre, School of Chemistry, University of Leeds, Leeds, UK.
Chem Commun (Camb). 2006 Dec 28(48):5000-2. doi: 10.1039/b614098j. Epub 2006 Nov 15.
Microwave assisted indirect functionalization of alcohols with 1,3-dimethylbarbituric acid followed by spirocyclisation employing a sequential one-pot Ir(III)/Pd(0) catalysed process, involving the formation of three new C-C bonds, one spirocyclic ring and one di- or tri-substituted exocyclic alkene, is described.
描述了一种微波辅助的醇与1,3-二甲基巴比妥酸的间接官能化反应,随后采用顺序一锅法Ir(III)/Pd(0)催化过程进行螺环化反应,该过程涉及形成三个新的C-C键、一个螺环和一个二取代或三取代的环外烯烃。