来自人脑的环核苷酸磷酸二酯酶的三维结构。
Three-dimensional structure of a cyclic-nucleotide phosphodiesterase from human brain.
作者信息
Sakamoto Yasumitsu, Tanaka Nobutada, Ichimiya Tomomi, Kurihara Tadashi, Nakamura Kazuo T
机构信息
School of Pharmaceutical Sciences, Showa University, Tokyo 142-8555, Japan.
出版信息
Nucleic Acids Symp Ser (Oxf). 2004(48):157-8. doi: 10.1093/nass/48.1.157.
2',3'-Cyclic-nucleotide 3'-phosphodiesterase (CNP) is found mainly in the central nervous system of vertebrates and catalyzes the hydrolysis of 2',3'-cyclic nucleotides to produce 2'-nucleotides in vitro. Recently, CNP has been identified as a member of the 2H phosphoesterase superfamily. Here we have determined the crystal structure of the catalytic fragment of human CNP (hCNP-CF) at 1.3 A resolution.
2',3'-环核苷酸3'-磷酸二酯酶（CNP）主要存在于脊椎动物的中枢神经系统中，在体外催化2',3'-环核苷酸水解生成2'-核苷酸。最近，CNP已被鉴定为2H磷酸酯酶超家族的成员。在此，我们以1.3埃的分辨率确定了人CNP催化片段（hCNP-CF）的晶体结构。
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