Avrameas S
Unité d'Immunocytochimie, CNRS URA 359, Institut Pasteur, Paris, France.
Immunol Today. 1991 May;12(5):154-9. doi: 10.1016/S0167-5699(05)80045-3.
The immune system of normal unimmunized animals is characterized by the presence of B cells synthesizing and secreting mainly polyreactive, but also monoreactive, IgM and IgG natural antibodies that can react with a variety of self constituents. These antibodies, like the autoantibodies appearing in several immunopathological states, use the same genetic elements as the antibodies directed against environmental antigens, and seem to be encoded by unmutated germ-line genes. Accumulating evidence indicates that these natural auto-antibodies exert various biological roles, both related and unrelated to the immune system. In this article, Stratis Avrameas proposes that natural auto-antibodies, by interacting with the large number of self constituents present in an organism, establish an extensive dynamic network that contributes to the general homeostasis of the organism.
正常未免疫动物的免疫系统的特点是存在B细胞，这些B细胞主要合成和分泌多反应性的，但也有单反应性的IgM和IgG天然抗体，它们能与多种自身成分发生反应。这些抗体与出现在几种免疫病理状态下的自身抗体一样，使用与针对环境抗原的抗体相同的基因元件，似乎是由未突变的种系基因编码的。越来越多的证据表明，这些天然自身抗体发挥着各种生物学作用，与免疫系统相关或无关。在本文中，斯特拉蒂斯·阿夫拉梅阿斯提出，天然自身抗体通过与生物体中大量的自身成分相互作用，建立起一个广泛的动态网络，有助于生物体的总体稳态。
