Sánchez F, Fernández M M, Giménez M, Benlloch J M, Rodríguez-Alvarez M J, García de Quirós F, Lerche C h W, Pavón N, Palazón J A, Martínez J, Sebastiá A
Instituto de Física Corpuscular (CSIC- UV), Edificio Institutos de Paterna, P.O. Box 22085, E-46071, Valencia, Spain.
Med Phys. 2006 Nov;33(11):4210-20. doi: 10.1118/1.2358199.
We have developed two prototypes of portable gamma cameras for medical applications based on a previous prototype designed and tested by our group. These cameras use a CsI(Na) continuous scintillation crystal coupled to the new flat-panel-type multianode position-sensitive photomultiplier tube, H8500 from Hamamatsu Photonics. One of the prototypes, mainly intended for intrasurgical use, has a field of view of 44 x 44 mm2, and weighs 1.2 kg. Its intrinsic resolution is better than 1.5 mm and its energy resolution is about 13% at 140 keV. The second prototype, mainly intended for osteological, renal, mammary, and endocrine (thyroid, parathyroid, and suprarenal) scintigraphies, weighs a total of 2 kg. Its average spatial resolution is 2 mm; it has a field of view of 95 x 95 mm2, with an energy resolution of about 15% at 140 keV. The main advantages of these gamma camera prototypes with respect to those previously reported in the literature are high portability and low weight, with no significant loss of sensitivity and spatial resolution. All the electronic components are packed inside the mini gamma cameras, and no external electronic devices are required. The cameras are only connected through the universal serial bus port to a portable PC. In this paper, we present the design of the cameras and describe the procedures that have led us to choose their configuration together with the most important performance features of the cameras. For one of the prototypes, clinical tests on melanoma patients are presented and images are compared with those obtained with a conventional camera.
基于我们团队之前设计并测试的一个原型,我们开发了两款用于医学应用的便携式伽马相机。这些相机使用了耦合到来自滨松光子学公司的新型平板式多阳极位置灵敏光电倍增管H8500的CsI(Na)连续闪烁晶体。其中一款原型主要用于手术中,视野为44×44平方毫米,重1.2千克。其固有分辨率优于1.5毫米,在140keV时能量分辨率约为13%。第二款原型主要用于骨学、肾脏、乳腺和内分泌(甲状腺、甲状旁腺和肾上腺)闪烁扫描,总重2千克。其平均空间分辨率为2毫米;视野为95×95平方毫米,在140keV时能量分辨率约为15%。相对于文献中先前报道的那些伽马相机,这些伽马相机原型的主要优点是高便携性和低重量,且灵敏度和空间分辨率没有显著损失。所有电子元件都封装在迷你伽马相机内部,无需外部电子设备。相机仅通过通用串行总线端口连接到便携式个人计算机。在本文中,我们介绍了相机的设计,并描述了促使我们选择其配置的过程以及相机最重要的性能特征。对于其中一款原型,展示了对黑色素瘤患者的临床试验,并将图像与用传统相机获得的图像进行了比较。