Clark F M, Yeomans D C, Proudfit H K
Department of Pharmacology, University of Illinois, Chicago 60680.
Neurosci Lett. 1991 Apr 29;125(2):155-8. doi: 10.1016/0304-3940(91)90015-l.
We have recently described the spinal cord terminations of noradrenergic neurons located in the A5, A6 and A7 cell groups. However, recent reports from another laboratory, using similar experimental methods, have described results that are profoundly different. The present experiments were designed to determine whether these discrepant results are due to fundamental differences between the substrains of rats used in the conflicting experiments. To this end, retrograde tract tracing experiments were done using Sprague-Dawley rats from either Sasco, Inc. or Harlan Sprague-Dawley, Inc. The results indicate that noradrenergic neurons in the pontine catecholamine cell groups exhibit remarkably different spinal cord projections in these two substrains of Sprague-Dawley derived rats.
我们最近描述了位于A5、A6和A7细胞群的去甲肾上腺素能神经元的脊髓终末。然而，另一个实验室最近使用类似实验方法的报告描述了截然不同的结果。本实验旨在确定这些相互矛盾的结果是否是由于在相互冲突的实验中使用的大鼠亚系之间的根本差异所致。为此，使用来自Sasco公司或Harlan Sprague-Dawley公司的Sprague-Dawley大鼠进行了逆行束路追踪实验。结果表明，在这两个Sprague-Dawley衍生大鼠亚系中，脑桥儿茶酚胺细胞群中的去甲肾上腺素能神经元表现出明显不同的脊髓投射。
