爱泼斯坦-巴尔病毒引起的脑炎所致精神症状及认知功能障碍。

Psychiatric symptoms and cognitive dysfunction caused by Epstein-Barr virus-induced encephalitis.

作者信息

Behr Joachim, Schaefer Martin, Littmann Eckhard, Klingebiel Randolf, Heinz Andreas

机构信息

Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Charite Mitte, Schumannstr. 20/21, 10117 Berlin, Germany.

出版信息

Eur Psychiatry. 2006 Dec;21(8):521-2. doi: 10.1016/j.eurpsy.2005.02.008.

DOI:10.1016/j.eurpsy.2005.02.008

PMID:17161283

Abstract

Epstein-Barr virus (EBV) encephalitis is rare and shows a wide range of clinical manifestations. We report an immunocompromised patient with EBV encephalitis diagnosed by EBV-specific PCR and antibody testing in the cerebrospinal fluid who presented with psychiatric symptoms and cognitive dysfunction in the absence of any neurological impairments or infectious signs. Clinical recovery and clearance of cerebrospinal fluid EBV DNA appeared following ganciclovir treatment within 6 weeks.

摘要

爱泼斯坦-巴尔病毒（EBV）脑炎较为罕见，临床表现多样。我们报告了一例免疫功能低下的EBV脑炎患者，通过脑脊液中的EBV特异性聚合酶链反应（PCR）和抗体检测确诊，该患者在没有任何神经功能损害或感染迹象的情况下出现精神症状和认知功能障碍。更昔洛韦治疗6周内患者临床康复，脑脊液EBV DNA清除。