不可逃避电击后大鼠海马细胞增殖的延迟抑制
Delayed suppression of hippocampal cell proliferation in rats following inescapable shocks.
作者信息
Fornal Casimir A, Stevens Joanne, Barson Jessica R, Blakley Gregory G, Patterson-Buckendahl Patricia, Jacobs Barry L
机构信息
Program in Neuroscience, Princeton University, Princeton, NJ 08544, USA.
出版信息
Brain Res. 2007 Jan 26;1130(1):48-53. doi: 10.1016/j.brainres.2006.10.081. Epub 2006 Dec 11.
Abstract
Adult Sprague-Dawley rats were exposed to a single session of 100 inescapable tail shocks (IS). Bromodeoxyuridine (BrdU) was administered 1 h, 2 days or 7 days later and hippocampal cell proliferation (CP) was assessed after a 2-h survival period. Measures of plasma corticosterone (CORT) levels were also obtained. Despite a large increase in CORT immediately following IS, no associated change in CP was observed. In fact, the only significant change in CP was seen 7 days after IS, at a time when CORT was unchanged from control levels. These data raise questions about the general nature of the relationship between CORT and CP. They also suggest that, under some conditions, changes in hippocampal CP may emerge only after an "incubation period".
摘要
成年斯普拉格-道利大鼠接受了单次100次不可逃避的尾部电击（IS）。在1小时、2天或7天后给予溴脱氧尿苷（BrdU），并在2小时的存活期后评估海马细胞增殖（CP）。还获得了血浆皮质酮（CORT）水平的测量值。尽管在IS后立即CORT大幅增加，但未观察到CP有相关变化。事实上，CP的唯一显著变化出现在IS后7天，此时CORT与对照水平无变化。这些数据引发了关于CORT与CP之间关系的一般性质的问题。它们还表明，在某些情况下，海马CP的变化可能仅在“潜伏期”后才出现。
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