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眼睑黏液表皮样癌:一例报告并文献复习

Mucoepidermoid carcinoma of the eyelid: a case report and review of the literature.

作者信息

Zhang Hao, Yan Jianhua, Li Yongping, Zhang Ping

机构信息

Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.

出版信息

Yan Ke Xue Bao. 2005 Sep;21(3):152-7.

Abstract

PURPOSE

To report the clinical features, therapeutic method, and histopathological findings of a case of mucoepidermoid carcinoma in the lower eyelid and review the literature about the mucoepidermoid carcinoma arising from the eye.

METHODS

Case report and review of the literature.

RESULTS

An 88-year-old man developed a painless, indurated nodule in the left lower eyelid for two years and ulceration of the skin existed for a year. He underwent tumor resection and reconstruction of the eyelid. By histopathology, tumor cells showed an admixture of epidermoid and mucus-secreting cells, which was consistent with mucoepidermoid carcinoma. Mucoepidermoid carcinoma is a common malignant tumor of the salivary glands, but rare in the eye tissues among which conjunctiva and lacrimal gland are most commonly involved. It has a higher degree of malignancy than basal cell carcinoma and squamous cell carcinoma. It displays an unusual capacity of aggressive local invasion and recurs easily after simple excision and tumors may require enucleation or exenteration because of the involvement of the intraocular structures and/or orbit. Frequent follow-up is necessary for the patient after operation.

CONCLUSIONS

Mucoepidermoid carcinoma arising from the eye is rare and has a high degree of malignancy. It should be differentiated from other neoplasms such as basal cell carcinoma and squamous cell carcinoma.

摘要

目的

报告1例下睑黏液表皮样癌的临床特征、治疗方法及组织病理学表现,并复习眼部黏液表皮样癌的相关文献。

方法

病例报告及文献复习。

结果

一名88岁男性,左眼下睑出现无痛性硬结结节2年,皮肤溃疡1年。他接受了肿瘤切除及眼睑重建手术。组织病理学检查显示,肿瘤细胞由表皮样细胞和黏液分泌细胞混合组成,符合黏液表皮样癌的表现。黏液表皮样癌是涎腺常见的恶性肿瘤,但在眼部组织中罕见,其中结膜和泪腺最常受累。它的恶性程度高于基底细胞癌和鳞状细胞癌。它具有较强的局部侵袭能力,单纯切除后易复发,由于眼内结构和/或眼眶受累,肿瘤可能需要眼球摘除或眶内容物剜除术。术后患者需要频繁随访。

结论

眼部黏液表皮样癌罕见且恶性程度高。应与基底细胞癌和鳞状细胞癌等其他肿瘤相鉴别。

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