Chrystyn Henry
School of Pharmacy and Institute of Pharmaceutical Innovation, University of Bradford, Bradford, West Yorkshire, UK.
Clin Drug Investig. 2006;26(4):175-83. doi: 10.2165/00044011-200626040-00001.
The characteristics of an ideal inhaler are based around the design and formulation of the device, patient use and the clinical effect, together with concordance and patient preference. To ensure consistent drug delivery to the lungs, with regular adherence to the prescribed dosage regimen, it is essential that all these characteristics simultaneously interact to provide smooth and sustained therapeutic control affected only by the clinical status of the patient. The literature highlights that dose emission from an Easyhaler is fairly consistent irrespective of the inhalation technique used by patients of all age groups. Clinical studies have shown equivalence of this device to those frequently prescribed and that it is preferred by many patients. Although further research is required into the development of inhalation devices, the literature describing the Easyhaler dry powder inhaler indicates how an inhaler can closely meet the criteria for an ideal inhaler.
理想吸入器的特性基于设备的设计与配方、患者使用情况以及临床效果,同时还涉及顺应性和患者偏好。为确保药物持续稳定地输送至肺部,并使患者定期坚持规定的给药方案,所有这些特性必须同时相互作用,以提供仅受患者临床状况影响的平稳且持续的治疗控制。文献强调,无论各年龄组患者采用何种吸入技术,易纳器的剂量释放都相当一致。临床研究表明,该设备与常用处方设备等效,且受到许多患者的青睐。尽管吸入设备的研发仍需进一步研究,但描述易纳器干粉吸入器的文献表明了一种吸入器如何能紧密满足理想吸入器的标准。